upstream php {
server 127.0.0.1:9000;
}

server {
server_name domen.loc;

add_header X-Content-Type-Options nosniff;
add_header X-XSS-Protection “1; mode=block”;
add_header X-Robots-Tag none;
add_header X-Download-Options noopen;
add_header X-Permitted-Cross-Domain-Policies none;

# Путь к корневому каталогу установки
root /var/www/nextcloud/;

location = /robots.txt {
allow all;
log_not_found off;
access_log off;
}

location = /.well-known/carddav {
return 301 $scheme://$host/remote.php/dav;
}

location = /.well-known/caldav {
return 301 $scheme://$host/remote.php/dav;
}

# установить максимальный размер загружаемого файла
client_max_body_size 512M;
fastcgi_buffers 64 4K;

# Включить gzip, но не удалять заголовки ETag
gzip on;
gzip_vary on;
gzip_comp_level 4;
gzip_min_length 256;
gzip_proxied expired no-cache no-store private no_last_modified no_etag auth;
gzip_types application/atom+xml application/javascript application/json application/ld+json application/manifest+json application/rss+xml application/vnd.geo+json application/vnd.ms-fontobject application/x-font-ttf application/x-web-app-manifest+json application/xhtml+xml application/xml font/opentype image/bmp image/svg+xml image/x-icon text/cache-manifest text/css text/plain text/vcard text/vnd.rim.location.xloc text/vtt text/x-component text/x-cross-domain-policy;

location / {
rewrite ^ /index.php$request_uri;
}

location ~ ^/(?:build|tests|config|lib|3rdparty|templates|data)/ {
deny all;
}
location ~ ^/(?:\.|autotest|occ|issue|indie|db_|console) {
deny all;
}

location ~ ^/(?:index|remote|public|cron|core/ajax/update|status|ocs/v[12]|updater/.+|ocs-provider/.+)\.php(?:$|/) {
fastcgi_split_path_info ^(.+?\.php)(/.*)$;
include fastcgi_params;
fastcgi_param SCRIPT_FILENAME $document_root$fastcgi_script_name;
fastcgi_param PATH_INFO $fastcgi_path_info;
fastcgi_param HTTPS on;
#Avoid sending the security headers twice
fastcgi_param modHeadersAvailable true;
fastcgi_param front_controller_active true;
fastcgi_pass php;

fastcgi_intercept_errors on;
fastcgi_request_buffering off;
}

location ~ ^/(?:updater|ocs-provider)(?:$|/) {
try_files $uri/ =404;
index index.php;
}

# Добавление заголовка cache control для файлов js и css
# Убедитесь, что он находится ниже блока PHP
location ~ \.(?:css|js|woff|svg|gif)$ {
try_files $uri /index.php$request_uri;
add_header Cache-Control “public, max-age=15778463”;

add_header X-Content-Type-Options nosniff;
add_header X-XSS-Protection “1; mode=block”;
add_header X-Robots-Tag none;
add_header X-Download-Options noopen;
add_header X-Permitted-Cross-Domain-Policies none;
# Необязательно: не журналировать доступ к ресурсам
access_log off;
}

location ~ \.(?:png|html|ttf|ico|jpg|jpeg)$ {
try_files $uri /index.php$request_uri;
# Необязательно: не регистрировать доступ к другим ресурсам
access_log off;
}
}

После сохранения и проверки, выдаёт:
# nginx -t
nginx: [emerg] unknown directive "mode=block”" in /etc/nginx/conf.d/alexcl.ru.conf:9
nginx: configuration file /etc/nginx/nginx.conf test failed