http://www.phoronix.com/scan.php?page=news_item&px=Intel-ME-Cleaning
Via an open-source, third-party tool called me_cleaner it's possible to partially deblob Intel's ME firmware images by removing any unnecessary partitions from the firmware, reducing its ability to interface with the system. The me_cleaner works not only with free software firmware images like Coreboot/Libreboot but can also work with factory-blobbed images. I was able to confirm with a Coreboot developer that this program can disable the ME on older boards or devices with BootGuard and disable Secure Boot. This is all done with a Python script.